TA的每日心情 | 2018-10-15 10:59 |
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Antidiabetics + NSAIDs
No adverse interaction normally occurs between most NSAIDs and antidiabetics. However, there are isolated cases of hypoglycaemia in patients given fenclofenac with chlorpropamide and metformin, ibuprofen with glibenclamide, indometacin with chlorpropamide, and naproxen with glibenclamide and metformin. Rofecoxib may have been a precipitating factor in a case of acute renal failure and metformin-associated lactic acidosis. The risk of fluid retention with pioglitazone or rosiglitazone is increased by the NSAIDs.
——Stockley's Drug interactions
翻译一下:降糖药+NSAIDS
大部分NSAIDS与降糖药没有不良的相互作用。然而,患者在接受芬氯酸、氯苯磺丁脲和二甲双胍,布洛芬和格列苯脲,吲哚美辛和氯苯磺丁脲,萘普生和格列苯脲及二甲双胍时有发生低血糖的案例。罗非昔布可能是急性肾功能衰竭和二甲双胍相关性乳酸酸中毒的一个诱发因素。吡格列酮或罗格列酮引起体液潴留的风险会由于合用NSAIDS而增加。 |
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