环丙沙星的用法

喹诺酮类左氧氟沙星现国家要求日一次给药，环丙沙星仍日二次用药吗

环丙沙星是q12h给药的。400mg q12h给药24h AUC是在25.4的。资料来源是热病第43版

ABX指南上面推荐的MIC折点是在1-3μg/ml。针对不同菌株的。

CLSI-S24的折点数据我没找到。

http://www.ncbi.nlm.nih.gov/pubmed/22968336
Adv *******. 2012;57(2):217-23.
Pharmacokinetics and pharmacodynamics of ciprofloxacin in critically ill patients after the first intravenous administration of 400 mg.
Sza?ek E1, Tomczak H, Kamińska A, Grabowski T, Smuszkiewicz P, Matysiak K, Wolc A, Kaczmarek Z, Grze?kowiak E.
Abstract
PURPOSE:To investigate the pharmacokinetics and pharmacodynamics of ciprofloxacin in critically ill patients after the first intravenous administration of 400 mg.MATERIAL/METHODS:Plasma concentrations were measured in 20 critically ill patients (mean [SD]; age, 55.5 [16.5] years; weight, 80.3 [16.9] kg; and creatinine clearance, 110.0 [71.5] mL/min). Four blood samples were drawn at the following time points 0, 0.5, 6 , 8 hours after infusion. Ciprofloxacin concentrations were determined by high-performance liquid chromatography.RESULTS:In the cases where ciprofloxacin was applied in targeted antibiotic therapy the minimum inhibitory concentrations (MIC) were ≤0.5 mg/l. The maximum and minimum plasma concentrations of ciprofloxacin were 1.74 (0.58-7.90) and 0.45 (0.16-2.96) mg/l, respectively. The main pharmacokinetic parameters for ciprofloxacin in the analyzed patients were as follows: k(el), 0.21 h-1; t(1/2kel), 3.37 h; AUC(0-inf), 10.10 mg×h/l; AUMC(0-last), 15.36 mg×h(2)/l; MRT, 1.71 h; V(d), 214.8 l; Cl, 39.70 l/h. Considering the maximum value of MIC (0.5 mg/l) only 30% and 25% of analyzed patients had desired values of the PK/PD indexes AUIC>125 and C(max) /MIC>10, respectively.CONCLUSIONS:The target plasma concentrations after the first dose of ciprofloxacin were reached only in a few critically ill patients. Considerable inter-subject variability for PK/PD parameters in ICU patients requires systematic monitoring.

http://www.ncbi.nlm.nih.gov/pubmed/21928725
Acta Pol Pharm. 2011 Sep-Oct;68(5):777-83.
The PK/PD index (CMAX/MIC) for ciprofloxacin in patients with cystic fibrosis.
Sza?ek E1, Kamińska A, Gozdzik-Spychalska J, Grze?kowiak E, Batura-Gabryel H.
Abstract
In order to evaluate the efficacy of an antibacterial therapy, three basic PK/PD indexes were defined: the ratio between the maximum drug concentration obtained after a single dose and minimum inhibitory concentration MIC (CMAX/MIC), the ratio between the area under the curve of dependence between the drug concentration in blood and time within 24 hours to MIC (AUC24/MIC), and the time when the concentration of the drug in blood is higher than MIC (T > MIC). The aim of the study was an analysis of the pharmacokinetics of ciprofloxacin and the PK/PD: CMAX/MIC index in patients with cystic fibrosis. Six patients with cystic fibrosis, with the identified microbiological factor were subjected to the examination. The patients received ciprofloxacin in the dose of 400 mg/12 h (i.v.). Plasma drug concentration was measured by HPLC-UV method after the first dose (Cmax1) and at steady state (Cssmax, Cssmin). The following mean values of ciprofloxacin blood concentrations were obtained from the analyzed patients: Cmax1 = 2.34 (+/- 1.15) microg/mL, Cssmax = 2.49 (+/- 1.44) pg/mL, Cssmin = 0.42 (+/- 0.22) pg/mL. The mean values of the Cmax1/MIC and Cssmax/MIC indexes were 3.66 +/- 2.34) and 3.38 (+/-1.73), respectively. Low values of the Cmax/MIC index for ciprofloxacin in the analyzed patients may indicate too low concentrations of the drug in the blood in relation to the MIC value of pathogens and the need to verify the assumed administration scheme.

可以的

可以的

请问，可以的结果是日二次为好？

药的用法不是由国家来规定的

一般都是一日两次

特殊的喹诺酮类药物，一日两次给药

请问哪里 有文件说左氧要一天一次的啊？

国家药监局下发的左氧氟沙星药品说明书修订文件