11个问题 评估临床试验的合理性

Eleven questions to make sense of a trial

Answer : YES, NO, DONT KNOW

A Are the results of the trial valid ?
1. Did the review address a clearly focused issue ?
e.g. the population , intervention and or outcomes
2. Was the trial randomised ?
Was this done properly ?
3. Were all the subjects who entered accounted for in the results ?
Check for withdrawals , dropouts
Is it worth continuing  ??
4. Were the study personnel and patients ‘blind’ to treatments
5 Were the groups similar at the start of the study ?
6. Were groups equally treated apart from the intervention ?
B What are the results?
7. How large was the treatment effect ?
8. How precise was the estimate of the treatment effect ?
Confidence intervals ?
C Will the results help my local situation ?
9. Can the results be applied locally ?
10. Were all important outcomes considered ?
11 Are the benefits worth the harms and costs ?