该用户从未签到
|
临床药师网(linyao.net)免责声明
禁止发布任何可能侵犯版权的内容,否则将承担由此产生的全部侵权后果;提倡文明上网,净化网络环境!抵制低俗不良违法有害信息。
Role of HMG-CoA Reductase Inhibitors in Neurological Disorders: Progress to Date
羟甲基戊二酰辅酶A还原酶抑制剂在神经功能紊乱方面的作用
Abstract:
摘要:
Inhibitors of HMG-CoA reductase (statins) are cholesterol-lowering agents that dramatically
羟甲基戊二酰辅酶A还原酶抑制剂可以降低胆固醇,从而明显地降低心血管疾病的发病率和病死率。
reduce morbidity and mortality in patients with established cardiovascular disease. In
addition, they exhibit pleiotropic effects that operate independently of lipid modification.
另外,他们呈现出多种对油脂的独立的修饰作用。
Statin administration results in greater nitric oxide bioavailability, improved endothelial
给予他汀类药物可以导致NO的生物利用度增加,改善内皮细胞的功能,
function, enhanced cerebral blood flow, immune modulation with anti-inflammatory action,
增强大脑的血流量,免疫调节和抗炎作用,
decreased platelet aggregation and antioxidant activity. Some or all of these effects may
减少血小板聚集和抗氧化剂活性。其中某些作用可以改善神经系统紊乱的症状和转归。
improve outcome or ameliorate symptoms in neurological disorders. This article examines
the potential role of statins in treating stroke, Alzheimer's disease, multiple sclerosis and
这篇文章调查了他汀类药物在治疗休克、阿尔兹海默氏病、多发性硬化症和帕金森氏病的潜在作用。
Parkinson's disease. Studies are ongoing in this controversial area, but there are no firm
这个有争议的领域正在研究中,但是还没有肯定的结果。
conclusions. The appropriateness of initiating statin therapy for neurological disorders is not
目前,开始他汀类药物治疗神经系统紊乱的恰当性尚未被证实。
established at this time. The exception is stroke, in which recurrence is significantly reduced
但是,他汀类药物可以明显减少休克的复发。
by statin therapy. |
|