单硝酸异山梨酯类药物每天应用有极量吗？

最近查房发现我们医院心内科单硝酸异山梨酯每天口服加注射用量可以高达90mg。请问各位专家们这正常吗？该类药物有应用极量吗？谢谢

我们注射最大50mg
加口服20mgbid

tianji901 发表于 2013-1-9  11:26
我们注射最大50mg
加口服20mgbid

这药注射剂是贫血禁用，口服没这说明，为什么？

鸽子花 发表于 2013-1-9  16:37
这药注射剂是贫血禁用，口服没这说明，为什么？

使用硝酸酯的一个罕见的不良反应是高铁血红蛋白血症，贫血患者更容易发生

Some manufacturers and medical references consider the use of nitrates and nitrites to be contraindicated in patients with severe anemia. Nitrates and nitrites can cause methemoglobinemia, primarily in high-dose intravenous therapy or acute poisoning and in patients with NADH reductase deficiency. However, elevations of methemoglobin may also occur with commonly used dosages. While probably not of routine clinical significance, the increases may be important in certain patient populations such as those with coronary insufficiency or anemia.