TA的每日心情 | 2020-7-30 14:47 |
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ALBUMIN HUMAN - AHFS 16:00
Products
Albumin human is available in 20-, 50-, and 100-mL vials as a 25% aqueous solution. Each 100 mL of solution contains 25 g of serum albumin. Albumin human is also available as a 5% aqueous solution in 50-, 250-, 500-, and 1000-mL sizes. The products also contain sodium carbonate, sodium bicarbonate, sodium hydroxide, and/or acetic acid to adjust the pH. 2, 4 The products are heat-treated for inactivation of hepatitis viruses. Sodium caprylate and sodium N-acetyltryptophanate are added to the products as stabilizers to prevent denaturation during the heat treatment. 2
pH — From 6.4 to 7.4. 2, 4
Sodium Content — From 130 to 160 mEq/L. 2, 4
Trade Name(s) — Albuminar, Albutein, Albumarc, Buminate, Plasbumin
Administration
Albumin human is administered intravenously either undiluted or diluted in an intravenous infusion solution having sufficient osmolality to be safely administered. See Infusion Solutions below. 2, 4 Stability Albumin human has been variously described as clear amber to deep orange-brown and as a transparent or slightly opalescent pale straw to dark brown solution. The solution should not be used if it is turbid or contains a deposit. Since it contains no preservative, the manufacturer recommends use within four hours after opening the vial. 2, 4 The expiration date is five years after issue from the manufacturer if the labeling recommends storage between 2 and 8 or 10 °C, or not more than three years after issue from the manufacturer if the labeling recommends storage at temperatures not greater than 30 or 37 °C. 4 Freezing Solutions — Freezing the albumin human solutions may damage the container and result in contamination. 4 Exposure of albumin human to elevated temperatures of 55 and 70 °C results in increased degradation, including an increase in dimer formation and aggregation. 2295
Compatibility Information
Solution Mfr Mfr Conc/L Remarks Ref C/I
Dextrose 5% AB 5 g Physically compatible 3 C
Sodium chloride AB 5 g Physically compatible 3 C
摘自
Handbook on Injectable Drugs - 14th Ed. (2007)
BY stonejang@cpteamHRByd2 |
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