多重耐药定义

在很多PPT上都看到这句话，“2011年，欧洲疾病预防控制中心（ECDC）和美国疾病预防控制中心（CDC）制定了关于多重耐药、泛耐药和全耐药的专家共识”，有知道出处么，或者这篇共识。谢谢

Clin Microbiol Infect. 2012 Mar;18(3):268-81. doi: 10.1111/j.1469-0691.2011.03570.x. Epub 2011 Jul 27.

Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance.

Magiorakos AP1, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, Harbarth S, Hindler JF, Kahlmeter G, Olsson-Liljequist B, Paterson DL, Rice LB, Stelling J, Struelens MJ, Vatopoulos A, Weber JT, Monnet DL.

Many different definitions for multidrug-resistant (MDR), extensively drug-resistant (XDR) and pandrug-resistant (PDR) bacteria are being used in the medical literature to characterize the different patterns of resistance found in healthcare-associated, antimicrobial-resistant bacteria. A group of international experts came together through a joint initiative by the European Centre for Disease Prevention and Control (ECDC) and the Centers for Disease Control and Prevention (CDC), to create a standardized international terminology with which to describe acquired resistance profiles in Staphylococcus aureus, Enterococcus spp., Enterobacteriaceae (other than Salmonella and Shigella), Pseudomonas aeruginosa and Acinetobacter spp., all bacteria often responsible for healthcare-associated infections and prone to multidrug resistance. Epidemiologically significant antimicrobial categories were constructed for each bacterium. Lists of antimicrobial categories proposed for antimicrobial susceptibility testing were created using documents and breakpoints from the Clinical Laboratory Standards Institute (CLSI), the European Committee on Antimicrobial Susceptibility Testing (EUCAST) and the United States Food and Drug Administration (FDA). MDR was defined as acquired non-susceptibility to at least one agent in three or more antimicrobial categories, XDR was defined as non-susceptibility to at least one agent in all but two or fewer antimicrobial categories (i.e. bacterial isolates remain susceptible to only one or two categories) and PDR was defined as non-susceptibility to all agents in all antimicrobial categories. To ensure correct application of these definitions, bacterial isolates should be tested against all or nearly all of the antimicrobial agents within the antimicrobial categories and selective reporting and suppression of results should be avoided.

重复了，请路过的版主删掉。谢谢

有翻译过来的吗

行成于思lsc 发表于 2014-11-19  09:12
有翻译过来的吗

找到一个类似的，但是不是LZ要的那个

谢谢五楼同仁！

谢谢~

还有个疑问，MDR：对3类或3类以上 (每类 中1种或1种以上) 抗菌药物不敏感。其中1种或1种以上如何理解，例如头孢类，对头孢呋辛耐药，不能说明对头孢类都耐药吧。

lemontree 发表于 2014-11-19  10:57
还有个疑问，MDR：对3类或3类以上 (每类 中1种或1种以上) 抗菌药物不敏感。其中1种或1种以上如何理解，例如 ...

一般对一个头孢耐药这种很少见，你看一下药敏报告很可能会有好几个都是耐药或者中介，一个耐药的很少。MDR更不可能了

下载学习，加深以前的认识