报告一例使用氯吡格雷二级卒中预防并成功妊娠、分娩的病例和综述。

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有关在妊娠期间服用氯吡格雷对胎儿及产妇的潜在危险的报告很少。本文献报道一例就诊的33岁、妊娠40周，有多次前缺血性中风、短暂缺血性发作史的女性患者。该名患者从受孕前开始服用氯吡格雷进行卒中二级预防并在整个妊娠过程中维持治疗，没有中断或发生并发症。引产前7天停用氯吡格雷，一名健康的、无出血并发症或先天性异常的婴儿被经阴道分娩。 在产后12小时重新服用氯吡格雷，没有发生事故。据我们所知，这是第一例被报告的氯吡格雷用于在妊娠的二级卒中预防。就此，我们查阅了有关氯吡格雷在怀孕过程中使用的文献。基于现有的有限数据，怀孕使用氯吡格雷对产妇和新生儿没有发现显著毒性。然而，更深入地评价氯吡格雷在该患者人群中的疗效与安全性仍需要更多的研究。

Literature is scarce regarding the use of clopidogrel during pregnancy and the potential hazard to maternal and fetal health. We report a 33-year-old female, who presented to our clinic at 40 weeks gestation with a history of multiple prior ischemic strokes and transient ischemic attacks. The patient was placed on clopidogrel for secondary stroke prophylaxis（卒中二级预防） prior to conception（受孕前） and maintained therapy（维持治疗） throughout pregnancy without interruption or complication. Clopidogrel was discontinued 7 days prior to induction of labor,（引产） and a healthy baby was vaginally delivered（阴道分娩） without bleeding complications（出血并发症） or congenital anomalies（先天性异常）. Clopidogrel was restarted 12 hours postpartum without an incident. To our knowledge, this is the first report of clopidogrel use in pregnancy for secondary stroke prophylaxis. We also provide a current review of the literature of the use of clopidogrel in pregnancy. Based on the limited data available, clopidogrel use in pregnancy has not demonstrated significant toxicity to either the mother or the newborn. However, additional studies are needed to further assess the efficacy and safety of this medication in this patient population.

不错，希望有更多的研究资料证明其妊娠安全性