请教,顺铂输液需要避光吗?

要求避光输液不是制剂稳定的要求，而是避免病人产生光敏反应。类似要求的药物还有依若沙星。

Light Effects — Although changes in the UV spectra of cisplatin solutions on exposure to intense light have long been recognized 317, their significance was questioned. It was reported that exposure to normal laboratory light for 72 hours had no significant effect on cisplatin's stability by HPLC. 635 More recently, however, Zieske et al. reported substantial cisplatin decomposition after exposure to typical laboratory light, a mixture of incandescent and fluorescent illumination. As much as 12% degraded to trichloroammineplatinate (II) after 25 hours. Cisplatin was most sensitive to light in the UV to blue region and had little sensitivity to yellow or red light. It was protected from light-induced degradation by low-actinic amber glass flasks but not by PVC bags, clear glass vials, or polyethylene syringes. The authors concluded that exposure to moderately intense white light for more than one hour should be avoided. 1647 The manufacturer recommends that a cisplatin solution removed from its amber vial be protected from light if it is not used within six hours. Even in the amber vial, the cisplatin solution should be discarded after seven days if exposed to fluorescent room light. 1-6/03

摘自 Handbook on Injectable Drugs - 14th Ed. (2007)
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BY stonejang
     stonejang@gmail.com

[ 本帖最后由 stonejang 于 2007-9-18 23:07 编辑 ]

顺铂：静滴时应避光。
另该药具有肾毒性，使用时应注意水化利尿，以免引起急性肾衰竭。

需要避光的，可以用遮光袋和避光输液器

我院20mg的齐鲁的粉针说明书上要求，我们就和护理部商定要用遮光袋和避光输液器，30mg豪森的注射剂说明书没有要求，我们也不做要求。因为遮光袋和避光输液器也要加重病人经济负担。

顺铂是最敏感的蓝色区域的紫外线光,白色强光照射，应避免超过一小时。

stonejang 发表于 2007-9-18  23:06
Light Effects — Although changes in the UV spectra of cisplatin solutions on exposure to intense li ...

老师，您那有这个的电子书吗？网上找不见下载资源

stonejang 发表于 2007-9-18  23:06
Light Effects — Although changes in the UV spectra of cisplatin solutions on exposure to intense li ...

请问老师，文中的white light， fluorescent room light，都是什么光？麻烦老师能不能拍下来具体的参考文献？我想仔细看看，谢谢。

文献研究还是建议避光的