博来霉素的单位mg和IU之间如何换算？

博来霉素的单位mg和IU之间如何换算？

原帖由 泉海 于 2008-8-27  11:20 发表
博来霉素的单位mg和IU之间如何换算？

1万单位换算成10毫克（青霉素除外），博来霉素15mg相当于1.5万国际单位

国际单位(IU)是表示抗生素效价和维生素活性的一种单位。

抗生素多用国际单位表示，有时也有以微克、毫克等重量单位表示，如青霉素G，1国际单位(IU)=0.6微克青霉素G钠纯结晶粉，或0.625微克钾盐，80万青霉素钠应为0.48克；1毫克杆菌肽=40单位，1毫克制霉菌素=3700单位。
1国际单位维生素A相当于0.60微克β胡萝卜素或0.30微克维生素A醇；1国际单位维生素E相当于1毫克维生素E醋酸脂。

①抗生素（效价：mg/IU）

以国际单位、微克、毫克等表示，

1 IU青霉素G = 0.6 mg青霉素G钠= 0.625 mg钾盐，

例如：80万IU青霉素钠 = 0.48g

其他抗生素： 1mg = 1000 IU

②维生素（效价：mg/IU）

维生素A、D、E一般用国际单位（IU）表示，其他维生素则以重量单位表示。

1IU维生素A= 0.3 mg 维生素A醇= 0.344 mg 维生素A醋酸酯。

1IU维生素D = 0.025 mg 结晶维生素D3的活性。

1IU维生素E =1mg DL-α生育酚醋酸酯。

③酶制剂

在饲料添加酶制剂，常用酶活性单位（FIU）表示，用含有活性单位去换算用量。

④激素常用国际单位（IU）。

Dosage nomenclature of bleomycin needs to be standardised to avoid errors

EDITOR---The consequences of errors involving anticancer drugs can be devastating. As correctly detailed by Seale, errors arise not only from inadequate time and training and supervision of medical staff but also from poorly written or ambiguous protocols.1 Such ambiguity is associated with the dosage nomenclature for bleomycin. Published protocols give bleomycin doses in milligrams (mg), international units (IU), or United States Pharmacopoeia units (USP units). This inconsistency in nomenclature seems to be universal and can lead to incorrect interpretation of medical literature.

Historically, bleomycin dosage has been described in terms of milligram potency (mg potency), in which 1 mg potency corresponded to 1 unit. In the original preparations 1 mg potency was also equivalent to 1 mg by weight (mg weight). Modifications and improvements in purification over time have meant that ampoules labelled as containing 15 mg---that is, 15 units---contained less than 15 mg weight of bleomycin.2

In 1995 labelling of bleomycin products in Australia changed from USP units to IU in line with changes in the British Pharmacopoeia and European Pharmacopoeia. The 10 mg vial, formerly labelled as containing 15 USP units, is now labelled as containing 15 000 IU. This has resulted in considerable confusion when older protocols are used or when referring to literature from the United States. Currently, the British Pharmacopoeia and European Pharmacopoeia specify 1500 IU per mg, while the United States Pharmacopoeia specifies 1.5-2 USP units per mg.2-4 Protocols that give bleomycin in mg or mg/m2 refer to mg potency, not mg weight. Therefore, 1.5-2 USP units is equivalent to 1500 IU, which is equivalent to 1 mg (by weight) or approximately 1.5 mg (by potency).

Considerable problems arise when bleomycin nomenclature is stated as mg or mg/m2. We have anecdotal evidence of patients prescribed bleomycin 30 mg as part of the bleomycin, etoposide, cisplatin protocol (BEP), erroneously receiving 45 000 IU. In the original protocol the total dose of bleomycin is specified as 30 units.5 This refers to 30 mg potency (not 30 mg weight), which is equivalent to 30 USP units or 30 000 IU.

This highlights the essential need for bleomycin dosages to be stated in terms of units (USP units in the United States or IU in Europe, the United Kingdom, and Australia), and not as mg or mg/m2. Otherwise, the risk of misinterpretation, incorrect conversion, and potential overdose of bleomycin is considerable. Standardisation of dosage nomenclature is one way of minimising errors with cytotoxic chemotherapy.

Angela Stefanou, senior pharmacist.
Drug Information Service, Peter MacCallum Cancer Institute, St Andrew's Place, East Melbourne, 3002, Australia StefanouAngela@petermac.unimelb.edu.au

Jim Siderov, senior pharmacist.
Research and Cancer Services, Austin and Repatriation Medical Centre, Heidelberg, 3084, Australia

On behalf of the Society of Hospital Pharmacists of Australia Committee of Specialty Practice in Oncology.


1.         Seale JRC. Not again! BMJ 2001; 322: 548. (3 March.)
2.         Parfitt K, ed. Martindale. The complete drug reference. 32nd ed. London: Pharmaceutical Press, 1999:507-509.
3.         United States Pharmacopoeial Convention. The United States pharmacopoeia, 24th revision, and the national formulary, 19th ed. Rockville, MD: USPC, 1999. (With supplements.)
4.         British Pharmacopoeia Commission. British pharmacopoeia. London: HMSO, 1993. (With addenda.)
5.         Williams SD, Birch R, Einhorn LH, Irwin L, Greco FA, Loehrer PJ. Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. N Engl J Med 1987; 316: 1435-1440[Abstract].
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时间挺长了。。。。
中心意思：
1.过去工艺不行，1mg(实际重量)=1mg(疗效重量)=1(uint,自己理解应该是USP unit)
2.工艺提高了，1mg（实际重量)>1mg(疗效重量）=1（uint,自己理解应该是USP unit)
3.1995年，不用USP unit 改成 IU 了（英国及欧洲药典）
4.现在（作者发表时间2001年），1.5-2 USP units =1500IU=1mg（实际重量）=1.5mg(疗效重量），而Protocols（规约，不知道包不包括说明书）们mg 或  mg/m2 指的是（疗效重量）
5.他还贱贱的举个例子，说有个患者在化疗联合方案里处方30mg博**霉素,却错误的执行了45000IU，应该是30mg(疗效重量）而非30mg(实际重量），30mg(疗效重量）=30 USP units or 30 000 IU.
6.他还呼吁别乱搞了，容易出错，建议大家统一单位。
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我不是搞肿瘤专科的，只是纸上谈兵罢了。。。。。2楼和3楼都对，经检验。。。。

8910 units of bleomycin complex A2/B2 are contained in 5 mg of bleomycin complex in one ampoule of the first International Reference Preparation (1980). The Ph. Eur. 5.5 specifies a potency of not less than 1500 international units per mg, calculated with reference to the dried substance. These units differ from those used by the USP: Bleomycin Sulfate (USP 29) contains 1.5 to 2.0 units of bleomycin in each mg. A change in the labelling of preparations in the UK, from units equivalent to those of the USP to international units in line with the Ph. Eur., resulted in an apparent but artefactual increase in UK doses by a factor of 1000.

In some countries doses were formerly described in terms of mg-potency, where 1 mg-potency corresponded to 1 unit. In the original preparation 1 mg-potency was equivalent to 1 mg-weight but improvements in purification of the product led to a situation in which ampoules labelled as containing 15 mg (i.e. 15 units) contained far fewer mg-weight of bleomycin.

非常感谢！

十分感谢

非常感谢，谢谢分享！

白桦林2013 发表于 2015-7-22  21:37
十分感谢

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