伐仑克林(辉瑞公司冠名为Chantix)增加自杀、抑郁的高风险

资料来源：Medscape Education Clinical Briefs
Varenicline (Chantix, Pfizer) is associated with a significantly increased risk for suicidal behavior and depression, according to new research.

In a study of more than 13,000 cases of adverse events involving smoking cessation products over the course of 13 years, investigators found that 90% of the reports of self-injurious behavior or depression were associated with the use of varenicline. Bupropion and nicotine replacement products were responsible for the remaining 7% and 3%, respectively.

"This should not be a first-line drug. If you start with the others, [and] they don't work, and you have to use a drug, then you use Chantix. But you must monitor the mental status of patients who use it," coinvestigator Curt D. Furberg, MD, PhD, professor of public health sciences at Wake Forest Baptist Medical Center in Winston-Salem, North Carolina, told Medscape Medical News.

"Ideally, I think it should come off the market, but that is not realistic. So a more realistic recommendation is to restrict its use."