TA的每日心情 | 2018-10-15 10:59 |
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这是Martindale35版中关于干扰素α的命名法,及干扰素α-2a、2b和2c结构上的差异。α干扰素不管其亚型如何,作用相差不大。
Nomenclature.
Interferon alfa may be derived from leucocytes or lymphoblasts as well as through recombinant DNA technology. Sub-species of the human alfa gene may produce interferon alfa with protein variants or a mixture of proteins. The protein variants may be designated by a number (as in interferon alfa-2) which may be further qualified by a letter to indicate the amino-acid sequences at positions 23 and 34. Interferon alfa-2a has lysine at 23 and histidine at 34, interferon alfa-2b has arginine at 23 and histidine at 34, and interferon alfa-2c has arginine at both positions. In the case of a mixture of proteins an alphanumeric designation is given (as in interferon alfa-n1). Interferon alfacon-1 varies from interferon alfa-2 in 20 of 166 amino acids. |
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