氨茶碱和氢化考的松琥珀酸钠配伍

大家都知道氨茶碱和氢化考的松琥珀酸钠有配伍禁忌，不能混在一起同时使用，可有谁知道是为什么呢？是药理性质决定，还是两药本身的理化性质决定？

可能是氢化可的松与氨茶碱合用时会导致茶碱的浓度升高吧，这是我在martindale35版上看到的氨茶碱项下的部分内容----------
与Corticosteroids相互作用：
In 3 patients with acute severe asthma given aminophylline intravenously, serum-theophylline concentrations rose rapidly from the therapeutic range to between 40 and 50 micrograms/mL when hydrocortisone was given intravenously. In studies in healthy subjects, no significant changes in serum-theophylline concentrations were noted when hydrocortisone, methylprednisolone,or prednisone were given, although there was a trend towards increased theophylline clearance during corticosteroid therapy.In preterm neonates, exposure to betamethasone in utero stimulated the hepatic metabolism of theophylline, but did not affect dosage requirements.
The possibility that adverse effects such as hypokalaemia may be potentiated by use of theophylline with corticosteroids should be borne in mind.

琥珀酸性质：HOOCCH2CH2COOH 学名丁二酸。因存在于琥珀内而得名。无色晶体。相对密度1.572（25℃）。熔点185℃。沸点235℃（分解）。溶于水，微溶于乙醇、乙mi、无水甘油和丙酮。在沸点时脱水而成酸酐。主要用于制备琥珀酸酐等五元杂环化合物。在医药上用作抗痉挛剂、祛痰剂和利尿剂。在分析化学中用作从其他金属分离铁的试剂。也用于制备醇酸树脂、喷漆和染料等。由顺丁烯二酸或反丁烯二酸氢化，或由酒石酸铵发酵制得 。
酸性琥珀酸与氨茶碱存在配伍禁忌！

了解了，琥珀酸因呈酸性，而与呈弱碱性的氨茶碱存在配伍禁忌，而氢化考的松琥珀酸钠与氨茶碱合用，可能是会降低氨茶碱的肝脏清除率，而使氨茶碱的血药浓度升高。谢谢二位版主！

看了很受启发，非常谢谢！

学习受教了

受教了，谢谢大家！